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Fig. 3j | Cholinergic markers in the in-vitro derived motor neurons

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posted on 2025-04-09, 11:58 authored by Christoph SchweingruberChristoph Schweingruber
<p dir="ltr">This item is part of the <b>Figshare Project</b>:<br><b>Early mitochondrial dysfunction revealed across FUS- and TARDBP-ALS at single cell resolution</b></p><p><br></p><p dir="ltr">From <i>Data Availability Statement</i> for the paper in <i>Nature Communications</i> entitled:</p><p dir="ltr"><b>Single-cell RNA sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS</b></p><p dir="ltr">"We have deposited all raw and processed RNA sequencing data generated in this study on the NCBI Gene Expression Omnibus (GEO) under the accession number GSE226482. The <i>C9orf72</i>-ALS bulk RNA sequencing data was retrieved directly from the authors of the study.</p><p dir="ltr">[Items under this Figshare Project contain:] "Scans of fluorescent western blots, raw imaging files from confocal microscopy, the analysis files from Opera Phenix, qPCR data sets, and Seahorse assay result files."</p><p>--------------------------------------------</p><p dir="ltr">[Item specific description:]</p><p dir="ltr">Confocal immunofluorescence microscopy in in-vitro derived ALS mutant motor neurons with cholinergic marker and motor neuron markers.</p><p dir="ltr">Information about the file format CZI can be found here: <a href="https://www.zeiss.com/microscopy/en/products/software/zeiss-zen/czi-image-file-format.html" rel="noreferrer" target="_blank">https://www.zeiss.com/microscopy/en/products/software/zeiss-zen/czi-image-file-format.html</a></p>

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Associated Publication

Schweingruber, C., Nijssen, J., Mechtersheimer, J. et al. (2025): Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS. Nat Commun 16, 4633. https://doi.org/10.1038/s41467-025-59679-1

Affiliation (institution of first SU-affiliated author)

  • 431 Institutionen för biokemi och biofysik (DBB) | Department of Biochemistry and Biophysics (DBB)

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