Eva Hedlund

Publications

• Altered perivascular fibroblast activity precedes ALS disease onset.
• Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.
• Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
• Single-Cell mRNA-Seq of In Vitro-Derived Human Neurons Using Smart-Seq2.
• Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease.
• Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience.
• Cross disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology
• Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations.
• The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis
• Single-cell RNA sequencing: Technical advancements and biological applications
• Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
• Characterization of molecular mechanisms underlying the axonal Charcot-Marie-Tooth neuropathy caused by MORC2 mutations
• A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate
• Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling
• Disrupted function of lactate transporter MCT1, but not MCT4, in Schwann cells affects the maintenance of motor end-plate innervation
• Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS
• Synaptotagmin 13 is neuroprotective across motor neuron diseases
• Axon-Seq Decodes the Motor Axon Transcriptome and Its Modulation in Response to ALS
• Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain
• Modeling Motor Neuron Resilience in ALS Using Stem Cells
• Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease.
• ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.
• Intrinsic neuronal resilience as a tool for therapeutic discovery
• Intact single muscle fibres from SOD1G93A amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training‐like adaptations
• Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish.
• Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.
• Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells
• Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS
• Human motor neurons are rare and can be transcriptomically divided into known subtypes
• Single cell RNA sequencing in isogenic FUS- and TARDBP-mutant ALS lines reveals early mitochondrial dysfunction as a common pathway in motor neurons
• Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation.
• Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.
• Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
• Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis.
• Neuronal cell replacement in Parkinson's disease.
• Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy.
• The protective effects of β-lactam antibiotics in motor neuron disorders.
• Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.
• Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells.
• Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection.
• Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
• Cell therapy and stem cells in animal models of motor neuron disorders.
• Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation
• CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells
• LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing
• Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons
• Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
• LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy
• LCM-seq identifies robust markers of vulnerable and resistant human midbrain dopamine neurons
• Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations
• A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene.
• L1 CAM expression is increased surrounding the lesion site in rats with complete spinal cord transection as neonates.
• Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation.
• The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons.
• Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study.
• Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development.
• Differential Pax6 promoter activity and transcript expression during forebrain development.
• Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation.
• Cytochrome P450 in the brain; a review.
• Cytochrome P450 in the brain: 2B or not 2B.
• Extrahepatic cytochrome P450: role in in situ toxicity and cell-specific hormone sensitivity.
• Cytochrome P450 in the breast and brain: role in tissue-specific activation of xenobiotics.
• Cytochrome P4502D4 in the brain: specific neuronal regulation by clozapine and toluene.